A clinical study on Graves' disease was made to 35 patients who received operation at the department of surgery of Asan medical center from July. 1989 to Dec. 1992.
@ES The results were as follows.
@EN 1) Male to female ratio was 1:2.9 and median age at operation was 26 years with highest incidence in the second and first decade.
2) Almost all of patients had neck mass, palpitation and sweating. Other symptoms were fatigue, weight loss, exophthalmus, tremor nervousness, irregular mentruation, headache, and dyspnea in the order of decreasing frequency.
3) In thyroid function test, initial mean value of T3 and T4 was 501.2 ng/dl and 14.7ug/dl, postoperative mean value of T3 and T4 was 138.9 ng/dl and 7.66 ug/dl espectively. Radioiodine uptake was increased in all cases.
4) As a preoperative preparation, antithyroid drug, Lugol solution and propranolol were given to 22 patients(62.9%) and antithyroid drug and Lugol solution were given to 13 patients(37.1%) .
5) Methods of operation were bilateral subtotal thyroidectomy in 19 patients, unilateral total and contralateral subtotal lobectomy in 15 patients, and lobectomy with isthmectomy in 1 patient, The estimated average weight of remaining thyoid
tissue was
5.6 grams.
6) Postoperative complications were symptomatic transient hypocalcemia in 6 cases(17.1%) and transient voice change in 2 cases(5.7%) but there was no permanent hypoparathyroidism, recurrent laryngeal nerve injury or postoperative death.
7) Follow up period was 3 to 36 months(mean 8.5 months) and there were euthyroids in 22 patients(62.9%), latent hypothyroids in 9 patients(25.7%), hyperthyroids in 3 patients(8.6%), and hypothyroid in 1 patient(2.9%).
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